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Lysine-Derived Urethane Surgical Adhesive Prevents Seroma Formation in a Canine Abdominoplasty Model

Gilbert, Thomas W. Ph.D.; Badylak, Stephen F. D.V.M., M.D., Ph.D.; Gusenoff, Jeffrey M.D.; Beckman, Eric J. Ph.D.; Clower, Dottie M. Ph.D.; Daly, Patrick; Rubin, J Peter M.D.

Plastic and Reconstructive Surgery: July 2008 - Volume 122 - Issue 1 - p 95-102
doi: 10.1097/PRS.0b013e31817743b8
Experimental: Original Articles

Background: Seroma formation is a common postoperative complication following many surgical procedures, including abdominoplasty. Several approaches have been investigated to prevent seroma formation by draining fluid or attempting to eliminate dead space, but these approaches have limited effectiveness.

Methods: A canine model of abdominoplasty was developed that reliably produced seroma formation. Bilateral subcutaneous pockets were created in the ventrolateral abdominal wall and additional tissue damage was inflicted using electrocautery. On one side, the tissue layers were treated with a lysine-derived urethane adhesive before closure, whereas the control side received no treatment before standard closure of the incision.

Results: Seroma formation (60 ± 45 ml) was observed on the control side, whereas the treated side had adherence between the tissue layers and minimal if any fluid accumulation (1.7 ± 1.4 ml) (p < 0.01) (n = 7). The adhesive invoked little or no cellular response, based on histologic examination of the tissue.

Conclusion: The urethane surgical adhesive was effective in preventing the formation of seroma in this canine abdominoplasty model.

Pittsburgh, Pa.

From the McGowan Institute for Regenerative Medicine and the Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, and Cohera Medical, Inc.

Received for publication August 18, 2007; accepted October 22, 2007.

Disclosure: Cohera Medical was solely responsible for funding the present study. Eric J. Beckman, Ph.D., Dottie M. Clower, Ph.D., and Patrick Daly are associated with Cohera Medical, Inc., and have a financial interest in the commercialization of the surgical adhesive. Eric J. Beckman, Ph.D., has patents issued and pending related to the surgical adhesive. Dr. J. Peter Rubin is a paid advisor to Cohera Medical, Inc.

J. Peter Rubin, M.D.; Division of Plastic Surgery; University of Pittsburgh; 682 Scaife Hall; 3550 Terrace Street; Pittsburgh, Pa. 15261;

©2008American Society of Plastic Surgeons