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An Overview of Permanent and Semipermanent Fillers

Broder, Kevin W. M.D.; Cohen, Steven R. M.D.

Plastic and Reconstructive Surgery: September 1, 2006 - Volume 118 - Issue 3S - p 7S-14S
doi: 10.1097/01.prs.0000234900.26676.0b

Summary: The demand for safe, effective, long-lasting, biocompatible dermal filler materials is increasing. Many products that include synthetic polymers and autologous tissue have emerged that attempt to meet these criteria. An overview of injectable permanent fillers, including ArteFill, Aquamid, and silicone, and semipermanent fillers, including Radiesse, Sculptra, and autologous fat, is presented. A discussion of their composition, histologic characteristics, antigenicity, U.S. Food and Drug Administration approval status, indications for use, efficacy, injection technique, and adverse effects is provided.

San Diego, Calif.

From the Division of Plastic and Reconstructive Surgery, University of California.

Received for publication January 6, 2006; accepted May 12, 2006.

For a complete list of the FDA status and approved uses for the fillers mentioned in this article, please see the information throughout the article or visit the following Web sites: or

Steven R. Cohen, M.D.; FACESplus Aesthetic Facility; 8899 University Center Lane, Suite 350; La Jolla, Calif. 92122;

©2006American Society of Plastic Surgeons