Wound Healing: An Overview : Plastic and Reconstructive Surgery

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Wound Healing: An Overview

Broughton, George II M.D., Ph.D., COL., M.C., U.S.A.; Janis, Jeffrey E. M.D.; Attinger, Christopher E. M.D.

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Plastic and Reconstructive Surgery 117(7S):p 1e-S-32e-S, June 2006. | DOI: 10.1097/01.prs.0000222562.60260.f9


Learning Objectives: 

After studying this article, the participant should be able to: 1. Describe the actions of inflammatory mediators, growth factors, and nitric oxide involved in wound healing. 2. Describe the different cellular elements and their function in wound healing. 3. Discuss the three phases of wound healing and the relationships between mediators and cells for each. 4. Discuss the similarities and differences between keloids and hypertrophic scar and the treatment options for each. 5. Discuss the systemic and external factors involved in wound healing. 6. Discuss future wound-healing opportunities.


Understanding wound healing today involves much more than simply stating that there are three phases: inflammation, proliferation, and maturation. Wound healing is a complex series of reactions and interactions among cells and “mediators.” Each year, new mediators are discovered and our understanding of inflammatory mediators and cellular interactions grows. This article will attempt to provide a concise overview on wound healing and wound management.

©2006American Society of Plastic Surgeons

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