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The Effect of Ketorolac on Microvascular Thrombosis in an Experimental Rabbit Model

Shufflebarger, John V. M.D.; Doyle, James Ph.D.; Roth, Tim M.S.; Maguire, Kevin M.D.; Rothkopf, Douglas M. M.D.

Plastic and Reconstructive Surgery: July 1996 - Volume 98 - Issue 1 - p 140–145
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This study was undertaken to evaluate the effect of ketorolac (Toradol), a potent cyclooxygenase inhibitor used for postoperative pain, on microvascular thrombosis in an established thrombosis model. Bilateral 3-mm arterial inversion grafts (n = 66) were constructed in the femoral arteries of New Zealand White rabbits. ALZET (ALZA Corporation, Palo Alto, Calif.) osmotic pumps were implanted in the external jugular veins for drug delivery. The blinded protocol called for the experimental animals to receive intravenous doses of ketorolac of 1.72 mg/kg per day (group 1) or 3.44 mg/kg per day (group 2), while control animals received equivalent volumes of saline. Patency was assessed at 7 days.

Whereas 52 percent (13 of 25) of control vessels remained patent, 70 percent (14 of 20) and 86 percent (18 of 21) of group 1 and group 2 vessels, respectively, were patent at 1 week. This decrease in microvascular thrombosis with delivery of ketorolac was statistically significant (p = 0.0094).

Ketorolac, at experimental doses approximating 9 and 18 mg IV q6h in a 70-kg man, demonstrated a statistically significant reduction in microvascular thrombosis. This study supports its use in clinical microvascular surgery.

Worcester, Mass.

From the Division of Plastic and Reconstructive Surgery, Department of Surgery, at the University of Massachusetts Medical Center. Received for publication November 30, 1994; revised May 30, 1995.

Presented at the Annual Meeting of the American Society for Reconstructive Microsurgery, on Marco Island, Florida, in January of 1995.

Douglas M. Rothkopf, M.D.

Division of Plastic and Reconstructive Surgery University of Massachusetts Medical Center 55 Lake Avenue North Worcester, Mass. 01655

©1996American Society of Plastic Surgeons