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Immunolocalization of Keratan Sulfate, Chondroitin-4-Sulfate, and Chondroitin-6-Sulfate in Periprosthetic Breast Capsules Exhibiting Synovial Metaplasia

Raso, Dominic S. M.D.; Schulte, Bradley A. Ph.D.

Plastic and Reconstructive Surgery: July 1996 - Volume 98 - Issue 1 - p 78–82
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The distribution of various proteoglycans and basement membrane components within 10 breast capsules with synovial metaplasia was assessed immunohistochemically. Immunoreactive keratan sulfate and chondroitin-4sulfate were present in many of the synovial metaplasia lining cells, suggesting active secretion of these proteoglycans into the intraprosthetic space. In contrast, chondroitin-6-sulfate was confined to the extracellular matrix of the underlying supporting fibrous capsule. Type IV collagen and laminin were not associated with the synovial metaplasia lining, thus confirming the absence of a basement membrane, as previously indicated by morphologic analysis. As with tendon reconstruction, the development and maintenance of a synovial metaplasia lining that secretes lubricating factors such as proteoglycans may be beneficial for decreased capsular contracture.

Charleston, S.C.

From the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina. Received for publication December 7, 1994; revised March 27, 1995.

Dominic S. Raso, M.D.

Department of Pathology and Laboratory Medicine Medical University of South Carolina 171 Ashley Avenue Charleston, S.C. 29425

©1996American Society of Plastic Surgeons