Vitamin D promotes epithelial immunity by upregulating antimicrobial peptides, including LL-37, which have bactericidal activity against Staphylococcus aureus. We found that children with vitamin D deficiency or insufficiency [25-hydroxyvitamin D <30 ng/mL] were more likely to present with recurrent, rather than primary, S. aureus skin or soft tissue infection. Vitamin D sufficiency may be one of a myriad of host and environmental factors that can be directly impacted to reduce the frequency of S. aureus skin and soft tissue infection.
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From the *Department of Pediatrics and †Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri
Accepted for publication November 20, 2014.
D.A.H. serves on the Scientific Advisory Board of BioVersys AG; other authors have no conflicts to declare. Funding for this project was provided by the Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital; the National Institutes of Health (NIH) grants K23-AI091690 and UL1-TR000448 and grant R01-HS021736 from the Agency for Healthcare Research and Quality (AHRQ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or AHRQ.
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Address for correspondence: Stephanie A. Fritz, MD, MSCI, Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8116, St. Louis, Missouri 63110. Email: email@example.com.