Opinion And AnalysisImperfect memory and the development of Haemophilus influenzae type b diseaseLUCAS, ALEXANDER H. PhD; GRANOFF, DAN M. MD Author Information From the Children’s Hospital Oakland Research Institute, Oakland, CA. Accepted for publication Oct. 16, 2000. Address for reprints: Dan M. Granoff, M.D., Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609. Fax 510-450-7910; E-mail [email protected]. The Pediatric Infectious Disease Journal 20(3):p 235-239, March 2001. Buy Abstract Considerable evidence indicates that both anticapsular antibody and immunologic memory play a role in immunity to Haemophilus influenzae type b (Hib) disease. The efficacy of memory (or antibody) cannot be expected to be 100%; therefore some individuals may develop invasive disease despite their having been naturally primed. The proportion of cases of H. influenzae type b disease with evidence of immunologic memory is related to both the efficacy of memory in preventing disease and the age-related prevalence of memory in the population. The task is to discern the relative contributions of antibody and memory in conferring protection and to determine the extent to which natural exposure and vaccination establish these two effector mechanisms. © 2001 Lippincott Williams & Wilkins, Inc.