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Instructive Cases

COVID-19 Can Cause Severe Intussusception in Infants

Case Report and Literature Review

Noviello, Carmine MD, PhD*,†; Bollettini, Taisia MD*; Mercedes, Romano MD, PhD*; Papparella, Alfonso MD, PhD; Nobile, Stefano MD, PhD; Cobellis, Giovanni MD, PhD*

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The Pediatric Infectious Disease Journal: November 2021 - Volume 40 - Issue 11 - p e437-e438
doi: 10.1097/INF.0000000000003257
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Intussusception is an acquired and acute condition in which a bowel segment (intussusceptum) is invaginated into an adjacent distal segment (intussuscipiens). While it may occur at any age, the highest incidence appears to be in infants between 4 and 9 months,1 and it is the most common cause of intestinal obstruction in this age group.2

Spontaneous reduction may occur, but lymphatic and venous obstruction may also develop as a result of edema of the bowel wall, causing arterial insufficiency with intestinal ischemia and necrosis. Any tract of the mesenteric intestine can be involved: ileocolic (85%), ileoileocolic (10%), appendicocolic, cecocolic or colocolic (2.5%), and jejunojejunal and ileoileal (2.5%). An intussusception can have a lead point, drawing the proximal bowel into the distal intestinal tract by peristaltic activity. The most common lead point is a Meckel diverticulum followed by polyps, duplication cysts, and appendix. Hemangiomas, carcinoid tumors, hamartomas from Peutz-Jeghers syndrome, and lipomas are, however, rare.

Primary or idiopathic intussusception, without a lead point, is the most frequent form (>80% of cases), especially in infants, and it is related to hypertrophied Peyer patches on the luminal surface of the distal small bowel.3 This problem can occur in the context of an upper respiratory tract infection or an episode of gastroenteritis, on account of the hypertrophied lymphoid tissue. Recently, it has also been associated with COVID-19.4


A 7-month-old male patient, with normal vaginal delivery after a full-term pregnancy (39+2 weeks) and without a relevant medical history, was brought to our pediatric emergency department because of 12 hours of abdominal pain, inappetence, diarrhea and vomiting (4 episodes), accompanied by sleepiness. He had been in contact with his grandmother who had been positive for COVID-19 10 days previously. The COVID-19 PCR test for the baby and his mother was reported to have been positive. He was apyretic, and his heart rate was 95 beats per minute, with an oxygen saturation of 100%. On physical examination, he appeared pale, ill, moderately dehydrated and lethargic. Laboratory tests revealed a normal blood count and D-dimer level of 27,891 ng/mL. Two hours later, he produced a stool mixed with blood and mucus. Urgent ultrasounds showed ileocolic intussusception through alternating rings of low and high echogenicity, representing the bowel wall and mesenteric fat in the transverse plane, and the “pseudokidney” sign on the longitudinal section. A contrast enema confirmed the diagnosis. The nonoperative procedure was unsuccessful; therefore, a laparotomic approach was necessary. Through a transverse right supraumbilical incision, the ileo-colic intussusceptum was identified and manipulated back to its normal position, but with difficulty. We found an ischemic portion of the intestine, which required ileocolic resection (3 cm of terminal ileus, cecum with appendix and 20 cm of ascending colon) and anastomosis.

The child was monitored for 48 hours in intensive care. After 5 days, he was gradually fed with adequate tolerance and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA was identified in his stool specimen.

Throughout the hospital course, he developed no complications and was discharged on the 15th day of his hospital stay when the COVID-19 test was negative. At 1-month follow-up, the patient was well.


As the onset of the COVID-19 pandemic is caused by SARS-CoV-2, attention is focused on adults with respiratory manifestations. Children are less affected than adults, specifically infants who tend to have an asymptomatic or mild presentation.5 The gastrointestinal symptoms of COVID-19 in children are more frequent and usually limited to abdominal pain, diarrhea and vomiting.6 Involvement of the gastrointestinal tract is related to the angiotensin II converting enzyme used by this virus to enter cells, not only in the lung tissue but also in the gastrointestinal tract, especially in enterocytes of the small intestine and colon.7 This is supported by a study that found that 8 of 10 COVID-19 positive children had positive rectal swabs, even after the disappearance of the virus from the upper respiratory tract.8 Intestinal infections, as with respiratory infections, can lead to inflammation through the production of cytokines and the release of chemokines.

The association between COVID-19 and intussusception may be related to mesenteric lymphadenopathy and hypertrophy of Peyer patches, evoking a local reactive mesenteric adenitis which causes an alteration in peristaltic intestinal movement or acts as a lead point for the intussusceptum.

To date, the presentation of COVID-19 as intussusception has been reported in 9 cases. Our patient is the first Italian case report and the only severe intussusception requiring an ileo-colic resection. To confirm a direct relationship between COVID-19 and intussusception, we wished to pursue RNA research on the resected intestinal tissue, but it was not possible with our available tests, so we looked for the presence of the virus in the stool specimen.

Nine infants with intussusception and laboratory-confirmed SARS-CoV-2 infection were described in the literature from January 2020 to February 2021 (Table 1).9–15 They were more or less the same age, predominantly male, and had initial intussusception symptoms; 4 of them also had respiratory symptoms.

TABLE 1. - Case Reports of Recent Literature Review
Author, Country Gender, Age (Months) Respiratory Symptoms Symptoms Treatment Outcome
Makrinioti et al, London, United Kingdom9 Case 1 F, 10 2 weeks before Bilious vomiting, currant jelly stool Pneumatic reduction Recovered
Surgical intervention
Makrinioti et al, Wuhan, China,9 Case 2 F, 10 No Currant jelly stool, vomiting Pneumatic reduction Deceased
Surgical intervention
Athamnah et al, Jordan, United States10 M, 2.5 No Vomiting Pneumatic reduction Recovered
Moazzam et al, Pakistan11 M, 4 1 week before Abdominal pain, currant jelly stool, drawing legs to abdomen Pneumatic reduction Recovered
Martínez-Castaño et al, Spain12 M, 6 No Abdominal cramps currant jelly stool vomiting Hydrostatic reduction Recovered
Mercado et al, Saltillo, Mexico,13 case 1 M, 8 No Feverish feeling, vomiting Surgical reduction Recovered
Mercado et al, Saltillo, Mexico,13 case 2 F, 7 1 week before Intermittent crying, 2 currant jelly stools Surgical reduction Recovered
Rajalakshmi et al, Chennai, India14 M, 8 No 6–7 episodes of vomiting, 2 episodes of blood-stained stools Pneumatic reduction Recovered
Bazuaye-Ekwuyas et al, Galveston, United States15 M, 9 4 days before Vomiting, abdominal pain, decreased oral intake, blood-streaked stool Hydrostatic reduction Recovered

Reduction without a surgical procedure was attempted in 5 of them, 3 had pneumatic reductions and 2 had hydrostatic reductions, guided by ultrasound or fluoroscopy. Another 4 patients required interventions, but none of them required ileo-colic resection because of invagination.

In conclusion, we report the first case of severe COVID-19-associated intussusception in a healthy infant. As knowledge of this virus is still evolving, we cannot define the nature of this association, but it is certainly important to know that intussusception can be an unconventional manifestation of COVID-19. It is even more important to suspect intussusception when a COVID-19 patient presents with abdominal pain, vomiting, constipation or blood in the stool. In these cases, timely diagnosis is crucial for adequate treatment and a good prognosis.


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intussusception; COVID-19; pediatric surgery; infants

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