Of the 105 children identified with intussusception, 91 had information on diagnostic method. Of these 91 children, 50.5% (46/91) had plain abdominal radiographs with 41.8% (38/91) had exploratory laporatomy (Table 4). Abdominal ultrasound was rarely used as a diagnostic tool (7.7%). Most patients 56.3% (36/64) presented to hospital after 4 days of the onset of symptoms (Table 3). Almost all children (98/101, 97.0%) had surgical intervention for intussusception (Table 4) most likely due to late presentation. The case fatality rate (CFR) was very high 33.7% (31/92), (Table 4). The annualized intussusception rates ranged from 1.0 to 15.1 per 100,000 at Choma and Livingstone General Hospitals, respectively, although the absolute numbers were relatively small (Table 1). However, the estimated annual intussusception incidence rate of 12 per 100,000 (67/111,612 over 5 years) in Lusaka is probably an underestimate (Table 1).
This baseline survey of intussusception rates in Zambia shows that intussusception is common in children below the age of 1 year (86.4% of recorded cases). This proportion of cases among infants is slightly higher than that in an earlier study of intussusception in Zambia during the early 1980s, which found that 61.2% occurred in infants.20 However, this finding is consistent with the findings from other regions of the world such as in Thailand where 86% of intussusception in children <2 years of age occurs in infants.21 In South Africa, many children (89%) with intussusception were <2 years.22
Intussusception was most common in infants between 3 and 8 months (70.8%) with a peak at 5–6 months (36.5%). If rotavirus vaccine is administered on time at the recommended ages of 6 and 10 weeks (for Rotarix vaccine) and 6, 10 and 14 weeks (for RotaTeq vaccine), then children will be vaccinated when the risk of intussusception is low. However, children who present for vaccinations late will be vaccinated when the background risk of intussusception is high. This age group critically overlaps with the recommended age for administering rotavirus vaccine rotavirus vaccine.18 There are often delayed vaccinations in infants in sub-Saharan Africa and especially so in rural areas.23 Perhaps, the age restrictions for rotavirus vaccine if strictly followed might improve the vaccinations of infants at the recommended age.
There is no seasonality in the distribution of intussusception cases seen in this study in Zambia. Infants and toddlers with intussusception were evenly distributed throughout the year over the 5-year period. In Thailand, there is a trend of increased intussusception rates during winter season.20 Studies from the temperate climates show that intussusception incidence does not coincide with the increased incidence rates in rotavirus infections in winter.15 In Zambia, rotavirus is seen throughout the year with a slight peak during the cool dry season.5–7 As found elsewhere, the survey shows a higher proportion of boys to girls of 1.4:1.
The overall CFR (33.7%) is very high in Zambian children compared with South Africa (2%) as all the 9 sites in the latter were specialist units.22 In Zambia, there is only 1 pediatric specialist unit situated at the teaching hospital in Lusaka. This high CFR is most likely due to late presentation to hospital and also delayed diagnosis of intussusception in hospitals. A diagnosis of intussusception in infants who present with bloody diarrhea may be delayed because these infants are considered to have dysentery and are managed as such in accordance with the WHO Integrated Management of Childhood Illnesses guidelines adopted by Zambia. Peripheral health centers strictly follow these guidelines and only when the condition worsens such infants are referred to hospitals. Organizing transport to take the children to hospital is time intensive as ambulance services are nonexistent and further increases the time to treatment. The situation is particularly grave in the rural health centers. Once a child arrives in hospital, there may be further delay in referral of suspected intussusception. Thus, by the time the infant is presented to surgeons, the patient is critically ill and the outcome of surgery is often unfavorable. Among those with complete data, almost all the patients diagnosed with intussusception underwent surgery (97.0%, 98/101) often due to late presentation to hospital. A major limitation of this survey is that the rate of intussusception is likely an underestimate as many children with this condition may die before they even reach the hospital. Of those who manage to reach the hospital, some will die before they are attended to by surgeons. In developed countries, mortality due to intussusception is rare.15
The annualized incidence rates of intussusception over 5 years ranges from 15.2 per 100,000 in Livingstone to 1.0 and 5.1 per 100,000 in smaller district hospitals. The relatively high incidence rate of intussusception (15.2 per 100,000) at Livingstone General Hospital may be an overestimate because this hospital serves as a referral centre for nearby districts so the population denominator for Livingstone District underestimates the catchment population for this hospital. The incidence rate (12.0 per 100,000) at the University Teaching Hospital, Lusaka, and the low rates in other district hospitals, ranging from 1.0 to 5.2 per 100,000, most likely reflect the differences in expertize and diagnostic facilities or differences in treatment seeking behavior and not necessarily a true difference in incidence. That is, children with intussusception in Lusaka presenting to the University Teaching Hospital may be more likely to be diagnosed as such compared with those presenting in other hospitals in the country. Alternatively, children with intussusception may be more likely to present for care in Lusaka than in some of the more rural districts. Thus, hospitals such as the Mine Hospitals in Chililabombwe and Chingola that have the expertize and facilities may have low incidence of intussusception because children with intussusception in the district do not seek care or are not referred from peripheral health centers.
There is paucity of published studies reporting the incidence rates of intussusception in infants and toddlers in Africa as most studies have been done in all ages or children <15 years.14 The estimated baseline incidence rate of intussusception in children <2 years in Lusaka is 12 per 100,000 children, which is really an underestimation. This is much lower than that reported in South Africa with the incidence of 32 per 100,000 in children <2 years.22 This rate is much lower than those cited in developed countries such as United Kingdom, The Netherlands and Australia, where the incidence rate range from about 66 to 120 per 100,00015 and lower in poor resource countries such as Venezuela, 24 per 100,00015 and Thailand 47.8 per 100,000.21 The incidence rates of intussusception reported in the developed countries are much higher than those in poor resource countries. This observation may be due to better health facilities and high levels of expertize in developed countries as almost all infants and young children with intussusception are investigated and that they also present earlier for medical attention. Therefore, our reported incidence rate of 12 per 100,000 in Lusaka is certainly an underestimate as not all infants and young children with intussusception are investigated and documented.
Our study has several limitations. First, in the retrospective part of the study, some files were not traced resulting in incomplete data on sex, age, diagnostic methods and outcomes for some cases. Second, we identified cases at hospitals that had the capacity to do emergency pediatric surgery. We missed cases among children who died in the community without presenting for care or who presented to other facilities and were not referred on to 1 of the study hospitals. Thus, the true incidence of intussusception in infants and young children is higher than that reported in our study.
Intussusception naturally occurs among infants and young children in Zambia and is most common in infants with a peak age of 5–6 months. The high CFR of 33.7% is due to both delayed presentation and delayed diagnosis in hospital. Delayed diagnosis was partly because of the similar symptoms and signs of intussusception in initial stages to dysentery, a common condition in Zambia. The incidence rate of intussusception in children <2 years in Lusaka, Zambia is estimated at 12 per 100,000. Active surveillance of intussusception in infants and young children is important for understanding trends in intussusception and should continue in these 9 participating hospitals in the baseline survey. This is particularly important as systems of surveillance for intussusception will be in place before rotavirus vaccine introduction in the national immunization program. Further, continued active surveillance for intussusception postrotavirus vaccine introduction will be crucial to monitor postmarketing surveillance of rotavirus vaccine safety.
We thank WHO/AFRO for funding this survey and the Ministry of Health, Zambia for allowing us to conduct the survey in the 9 hospitals. We further thank Prof. Mari Kirsten of Steve Biko Academic Hospital, Pretoria, Republic of South Africa for providing us with the questionnaire and her invaluable advice during the conduct of study and write up of the article.
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Keywords:© 2014 by Lippincott Williams & Wilkins, Inc.
intussusception; age group; 0–2 years; incidence rates; mortality; Zambia