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Optimizing Blood Collection and Processing for Quantiferon-TB Gold in-Tube Testing Gives Low Rates of Indeterminate Results: Clinical Implications

Kordy, Faisal MD*†; Waters, Valerie MD*†; Den-Hollander, Cathy BSc; Read, Stanley MD*†; Lam, Ray PHC-NP*†; Kitai, Ian MD*†

The Pediatric Infectious Disease Journal: January 2018 - Volume 37 - Issue 1 - p e22–e24
doi: 10.1097/INF.0000000000001732
Brief Reports

The rate of low-mitogen indeterminate interferon-gamma release assay results at a hospital with expert pediatric phlebotomy and rapid incubation of specimens was 0.96%. All low-mitogen indeterminate results were found to be associated with an immunocompromised or anergic state. We describe a child where an unexpected indeterminate interferon-gamma release assay test pointed to an underlying anergic condition and was of diagnostic significance.

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*Department of Paediatrics, Division of Infectious Diseases, The Hospital for Sick Children, Department of Paediatrics, and Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Ian Kitai, MD, Division of Infectious Diseases, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada. E-mail: ian.kitai@sickkids.ca.

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