The rate of low-mitogen indeterminate interferon-gamma release assay results at a hospital with expert pediatric phlebotomy and rapid incubation of specimens was 0.96%. All low-mitogen indeterminate results were found to be associated with an immunocompromised or anergic state. We describe a child where an unexpected indeterminate interferon-gamma release assay test pointed to an underlying anergic condition and was of diagnostic significance.
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*Department of Paediatrics, Division of Infectious Diseases, The Hospital for Sick Children, †Department of Paediatrics, and ‡Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
The authors have no funding or conflicts of interest to disclose.
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Address for correspondence: Ian Kitai, MD, Division of Infectious Diseases, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada. E-mail: email@example.com.