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Would Parents Consent To A Comparative Effectiveness Trial Of Oral Doxycycline Versus Intravenous Ceftriaxone For The Treatment Of Children With Lyme Meningitis?

Garro, Aris1; Koster, Michael1; LaRue, Molly2; Hipolito, Evelyn2; Congdon, Elizabeth2; Burnett, Kathleen3; Cullen, Nicole3; Nigrovic, Lise, E.4

The Pediatric Infectious Disease Journal: September 28, 2017 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/INF.0000000000001793
Brief Reports: PDF Only

Children with Lyme meningitis are often treated with intravenous ceftriaxone although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) would consent to their child participating. Parents would accept 2 additional days of symptoms (non-inferiority margin) with doxycycline even if ceftriaxone hastened symptom resolution.

1. Warren Alpert Medical School of Brown University and Rhode Island Hospital

2. Lifespan Corporation

3. Providence College

4. Division of Emergency Medicine, Boston Children’s Hospital

Reprints available on request to corresponding author at address above

Disclosure of Funding Support: None

Corresponding author: Aris Garro, MD, 125 Whipple Street, UEMF Suite, 3rd floor, Providence, RI 02908, Telephone: 401-480-8682, Email:

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