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Vaccinations and Malaria Chemoprophylaxis of Adolescents Traveling from Greece to International Destinations: A Nine-Year Prospective Study

Maltezou Helena C. MD PhD; Pavli, Androula MD; Theodoridou, Kalliopi MD, PhD; Katerelos, Panos Msc; Spilioti, Athina MD; Tedoma, Anastasia; Lymperi, Ioanna RN; Theodoridou, Maria MD, PhD
The Pediatric Infectious Disease Journal: Post Acceptance: September 06, 2017
doi: 10.1097/INF.0000000000001782
Vaccine Reports: PDF Only


There are few publications focusing on vaccination and malaria chemoprophylaxis in adolescent travelers. We assessed pre-travel vaccinations and malaria chemoprophylaxis of adolescents 12-18 old traveling from Greece to international destinations.


We prospectively studied 239 adolescents 12-18 years old during 2008-2016. A standard questionnaire was used to collect data.


Adolescents sought pre-travel services at a mean of 24.1 days before departure. Their main destinations were sub-Saharan Africa (79 adolescents; 33.1%), Latin America (56; 23.5%) and North America (26; 10.9%). Almost half (46.1%) planned to stay abroad for at least three months. Sixteen (7.4%) adolescents planned to visit friends and relatives. The yellow fever vaccine and the typhoid vaccine were the most frequently administered vaccines (74.1% and 20.5%, respectively), while the hepatitis A vaccine and the tetanus-diphtheria vaccine accounted for most routine vaccinations (18% and 14.2%, respectively). The rabies and the typhoid fever vaccines were administered inadequately to adolescents travelling to endemic areas. Malaria chemoprophylaxis should have been prescribed in many cases traveling to sub-Saharan Africa and the Indian subcontinent.


Only a small number of adolescents from Greece traveling abroad seek pre-travel counseling. We found significant gaps in typhoid fever and rabies vaccinations of adolescents traveling to endemic areas. We also found gaps in prescription of malaria chemoprophylaxis for those traveling to high-risk areas. There is a need to develop communication strategies to access adolescent travelers and improve appropriate vaccination and use of malaria chemoprophylaxis.

Disclosures: The authors have no conflicts of interest or funding to declare.

This work has been partially presented at the American Society for Microbiology 2017 Microbe Conference (New Orleans, United States; 1-5 June, 2017; Abstract: Friday-275)

Corresponding author: Dr. Maltezou, Department for Interventions in Health-Care Facilities, Hellenic Centre for Disease Control and Prevention, 3-5 Agrafon Street, Athens, 15123 Greece. Tel: 30-210-5212-175, E-mail address:

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