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Macro- and Microvascular Parameters Following Toxic Shock Syndrome

Chen, Katherine YH MBBS1, 2, 3; Li, Ling-Jun PhD4,5; Wong, Tien Y. PhD4,5; Cheung, Carol Y. PhD4,6; Curtis, Nigel PhD1, 2, 3; Cheung, Michael MD2,4; Burgner, David P. PhD1,2,5

The Pediatric Infectious Disease Journal: November 3, 2017 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/INF.0000000000001821
Brief Reports: PDF Only

Whether individuals who had toxic shock syndrome (TSS) in childhood have differences in macro- and retinal microvascular parameters indicative of increased cardiovascular risk is unknown. We found no evidence of adverse macrovascular changes in 22 TSS participants compared to 60 control participants. Microvascular comparisons showed a reduction in retinal total fractal dimension which has been associated with cardiovascular risk factors in children.

1Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Vic, Australia

2Department of Paediatrics, University of Melbourne, Vic, Australia

3Infectious Diseases Unit and Department of General Medicine, The Royal Children’s Hospital Melbourne, Vic, Australia

4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore

5Duke-NUS Medical School, National University of Singapore, Singapore

6Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong

7Heart Research Group, Murdoch Childrens Research Institute and Department of Cardiology, The Royal Children’s Hospital, Melbourne, Vic, Australia

8Department of Paediatrics, Monash University, Vic, Australia

Financial support: KYHC holds an Australian Government Research Training Program scholarship from The University of Melbourne and a Postgraduate Health Research Scholarship from Murdoch Children’s Research Institute. DPB holds a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1064629) and an honorary National Heart Foundation Future Leader Fellowship (100369). NC is an investigator on NHMRC project grant 1064408. Research at Murdoch Children’s Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group is supported by The RCH1000, The Royal Children’s Hospital Foundation and Big W. The sponsors had no involvement in the study design, collection, analysis, interpretation, and in the writing of this manuscript.

Acknowledgments: The authors wish to thank Jane Koleff from Murdoch Childrens Research Institute for training and providing technical support for the research staff, and the assistance of Greta Goldsmith BBiomedSc and Meg Kaegi BSc from the same institution in study logistics and data acquisition.

Conflict of Interest: The authors have no conflicts of interest

Corresponding author: Professor David Burgner, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, Victoria 3052. Australia. Tel: +61 3 99366730 Fax: +61 3 9348 1391 E-mail:

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