Levofloxacin is used for the treatment and prevention of multidrug-resistant tuberculosis in children, but current adult formulations are poorly palatable. A questionnaire administered to caregivers of 27 children taking a novel 100 mg dispersible taste-masked levofloxacin tablet found the new formulation to be more palatable (69%) and easier to prepare (81%) than the adult formulation. This formulation may assist children to better adhere to anti-tuberculous therapy.
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Child Health, Stellenbosch University, Cape Town
2Centre for International Child Health, Imperial College London
CONFLICT OF INTEREST: The authors have no conflicts of interest to declare.
SOURCES OF FUNDING: Joint Global Health Trials Scheme of the Department for International Development, UK (DFID), Wellcome Trust; Medical Research Council (MRC UK) (Grant # MR/M007340/1), South African Medical Research Council (SA MRC) Strategic Health Innovation Partnerships (SHIP) (PI: AC Hesseling); South African National Research Foundation SARChI Chair in Paediatric TB (A. Hesseling).
ACKNOWLEDGEMENTS: The authors thank the caregivers and children who participated in this study, and the staff of the Desmond Tutu TB Centre Paediatric Pharmacokinetics Unit.
CORRESPONDENCE: Dr Susan Purchase, Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Child Health, Stellenbosch University, Francie van Zijl Drive, Tygerberg, PO Box 241, Cape Town 8000; Tel: +27219389631 Fax: +27219389719 Email: firstname.lastname@example.org