Antimicrobial ReportsRapid Detection of Carbapenemase-producing Enterobacteriaceae From Blood Culture Bottles of Known CPE Carriers Real-world ExperienceKriger, Or MD*,†; Shatzman-Steuerman, Rachel MD†; Smollan, Gillian MD*; Belausov, Natasha MSc*; Sarkisian, Gayane Msc*; Amit, Sharon MD, PhD* Author Information From the *Clinical Microbiology Laboratory, Sheba Medical Center, Ramat-Gan, Israel †Pediatric Infectious Disease Unit, The Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center, Israel. Accepted for publication July 16, 2021 The study was funded by the research group with no external support. The authors have no conflicts of interest to disclose. Address for correspondence: Or Kriger, MD, Clinical Microbiology Laboratory, Sheba Medical Center, Ramat-Gan, Israel. E-mail: [email protected] The Pediatric Infectious Disease Journal: January 2022 - Volume 41 - Issue 1 - p 45-47 doi: 10.1097/INF.0000000000003311 Buy Metrics Abstract We used a rapid antigen test for the detection of carbapenemases directly from positive blood culture bottles of pediatric hemato-oncologic patients, known carriers of carbapenemase-producing enterobacteriaceae. Resistance mechanism was detected within 15 minutes of observing Gram-negative bacilli from a positive bottle, leading to treatment modification. This simple-to-use, inexpensive assay shortens the interval between empiric to tailored antimicrobial therapy. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.