HIV ReportsImproving Methods to Classify Perinatal versus Nonperinatal HIV Acquisition in Young Adolescents 10–14 Years of AgeTsondai, Priscilla Ruvimbo MD, MPH*; Davies, Mary-Ann MD, PhD*; Singtoroj, Thida PhD†; Maxwell, Nicola*; McGowan, Catherine C. MD‡; Songtaweesin, Wipaporn N. MBBS§; Technau, Karl-Günter PhD¶; Kariminia, Azar PhD∥; Chimbetete, Cleophas MD, PhD**; Succi, Regina C. M. MD, PhD††; Pinto, Jorge MD, DSc‡‡; Rouzier, Vanessa MD§§; Luque, Marco Tulio MD¶¶; Sohn, Annette H. MD†; for the IeDEA ConsortiumAuthor Information From the *Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa †TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand ‡Vanderbilt University Medical Center, Nashville, Tennessee §Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ¶Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, South Africa ∥The Kirby Institute, UNSW Sydney, Australia **Newlands Clinic, Harare, Zimbabwe ††Escola Paulista de Medicina, Pediatrics Department, Universidade Federal de Sao Paulo, Sao Paulo, Brazil ‡‡Universidade Federal de Minas Gerais, Belo Horizonte §§Les Centres GHESKIO, Port-au-Prince, Haiti ¶¶Instituto Hondureño de Seguridad Social and Hospital Escuela Universitario, Tegucigalpa, Honduras. Accepted for publication December 19, 2020 The International Epidemiology Databases to Evaluate AIDS (IeDEA) was supported by the US National Institutes of Health’s National Institute of Allergy and Infectious Diseases and, the Eunice Kennedy Shriver National Institute of Child Health and Human Development: Asia-Pacific (U01AI069907); CCASAnet (U01AI069923); Southern Africa (U01AI069924). This work was also funded by the US National Institutes of Health’s National Institute of Allergy and Infectious Diseases for GRADUATE (R21HD089859). This work is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. A.H.S. has received grant funding to her institution from ViiV Healthcare. The other authors have no conflicts of interest to disclose. M.-A.D. conceived and designed the study. C.C.M., W.N.S., K.-G.T. and C.C. collected the data. N.M. and T.S. contributed to the implementation of the research. P.R.T. performed the analysis and drafted the manuscript. M.-A.D. and A.H.S. supervised the findings of this work. All authors commented on the manuscript and have read and approved the final manuscript. Address for correspondence: Priscilla Ruvimbo Tsondai, MPH, MD, School of Public Health and Family Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa. E-mail: [email protected]. The Pediatric Infectious Disease Journal: May 2021 - Volume 40 - Issue 5 - p 453-456 doi: 10.1097/INF.0000000000003059 Buy Metrics Abstract Mode of HIV acquisition for adolescents with HIV is often not recorded within routine healthcare databases. Hence, age at enrollment in HIV care is often used as a proxy for perinatal versus nonperinatal infection. Using routine cohort data from adolescents presenting for HIV care 10–14 years of age, we developed logistic regression models to predict likely mode of infection. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.