Antimicrobial ReportsImpact of Antecedent Antibiotic Usage on Community-associated Clostridioides difficile Infection in PediatricsDang, Rebecca MD*; Alabaster, Amy MPH*; Miranda-Katz, Margot†; Parmar, Deepika MD*; Greenhow, Tara L. MD*Author Information From the *Department of Pediatrics, Division of Infectious Diseases, Kaiser Permanente Northern California, San Francisco, CA †Colby College, Waterville, ME. Accepted for publication October 4, 2020 Supported by a grant from the Kaiser Permanente Northern California Community Benefit Program. The authors have no conflicts of interest to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com). Address for correspondence: Tara L. Greenhow, MD, Department of Pediatrics, Division of Infectious Diseases, Kaiser Permanente Northern California, 2238 Geary Blvd, San Francisco, CA 94115. E-mail: [email protected]. The Pediatric Infectious Disease Journal: May 2021 - Volume 40 - Issue 5 - p 426-428 doi: 10.1097/INF.0000000000002991 Buy SDC Metrics Abstract Children exposed to antibiotics develop community-associated Clostridioides difficile infections in the 12 weeks following exposure. This secondary analysis was a retrospective review of children with filled prescriptions for commonly prescribed antibiotics between January 1, 2012, and December 31, 2016. Compared with amoxicillin, incident rates of community-associated Clostridioides difficile infections were highest following clindamycin, cephalosporins, and amoxicillin-clavulanate. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.