Antimicrobial ReportsEvaluating Ceftriaxone 80 mg/kg Administration by Rapid Intravenous Infusion—A Clinical Service EvaluationPatel, Sanjay MRCPCH*,†; Green, Helen BN*; Gray, Jacqueline BSc*; Rutter, Michelle BN*; Bevan, Amanda PhD*,‡; Hand, Kieran PhD§; Jones, Christine E. MRCPCH, PhD*,†,¶; Faust, Saul N. FRCPCH, PhD*,†,¶Author Information From the *Department of Paediatric Immunology & Infectious Diseases †NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre ‡Pharmacy Department, University Hospital Southampton NHS Foundation Trust §Faculty of Health Sciences ¶Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom. Accepted for publication August 9, 2020 No funding was obtained to conduct this service evaluation. S.N.F. is an UK National Institute for Health Research (NIHR) Senior Investigator. The authors have no conflicts of interest to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com) Address for correspondence: Saul N. Faust, FRCPCH, PhD, NIHR Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Mailpoint 218, Tremona Road, Southampton SO16 6YD, United Kingdom. E-mail: [email protected]. The Pediatric Infectious Disease Journal: February 2021 - Volume 40 - Issue 2 - p 128-129 doi: 10.1097/INF.0000000000002923 Buy SDC Metrics Abstract In pediatric ambulatory care, the speed of medication infusion can have major impact on healthcare staff workload and the number of children able to be treated by services designed to reduce inpatient length of stay. In many regions of the world, local and supraregional guidelines allow ceftriaxone infusions of ≥50 mg/kg in infants and children up to 12 years of age to be given over 10 minutes. The generic European summary of product characteristics for ceftriaxone does not state a specific infusion time for this dose range, although 1 manufacturers’ summary of product characteristics in the United Kingdom states a 30-minute minimum infusion time. We conducted a formal service evaluation of a change in practice at a large UK pediatric children’s hospital and demonstrated the clinical feasibility, safety, and high parent satisfaction of 10-minute ceftriaxone infusions for prescribed doses ≥50 mg/kg. This approach can improve patient flow within hospital-based ambulatory services as well as by community nursing teams administering antibiotics at home. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.