Original StudiesClinical Characteristics and Outcome Analysis of 94 Children With Brain Abscess in Beijing: A Single-center Retrospective StudyDou, Zhen-Zhen MMed*; Guo, Ling-Yun MD*; Liu, Lin-Lin MMed*; Li, Mu-Han MMed*; Hu, Hui-Li MD*; Hu, Bing MMed*; Guo, Xin MMed*; Chen, Tian-Ming MMed*; Chen, He-Ying MBBS*; Ge, Ming MMed†; Qian, Su-Yun MD‡; Zheng, Hu-Yong MD§; Li, Jiu-Wei MMed¶; Zhang, Wei-Hua MMed¶; Hei, Ming-Yan MD‖; Liu, Gang MD* Author Information From the *Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases †Department of Neurosurgery ‡Pediatric Intensive Care Unit §Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Hematology Oncology Center ¶Department of Neurology ‖Neonatal Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China. Accepted for publication August 27, 2020. This work was supported by the nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019XK320080], Pediatric Medical Coordinated Development Center of Beijing Municipal Administration (No. XTZD20180501) and Beijing Hospital Authority “Dengfeng” Talent Training Plan (DFL 20181201). The authors have no conflicts of interest to disclose. Informed consent was waived because this was a retrospectively study. We obtained patient data from the Medical Records and Statistics Room. We analyzed the data anonymously. The raw data were permitted by the Ethics Committee of Beijing Children’s Hospital Affiliated to Capital Medical University (2019-k-370). The datasets analyzed during the current study are available from the corresponding author on reasonable request. All of the authors had access to the full dataset (including the statistical reports and tables) and take responsibility for the integrity of the data and the accuracy of the data analysis. Z.-Z.D. and G.L. conceived and designed the study. Z.-Z.D., L.-Y.G., L.-L.L., M.-H.L., B.H., H.-L.H., T.-M.C., X.G., H.-Y.C., M.G., S.-Y.Q., H.-Y.Z., J.-W.L., W.-H.Z. and M.-Y.H. were involved in the case and sample collection, analysis and interpretation of the data. Z.-Z.D. complete draft the paper, Z.-Z.D., L.-Y.G., L.-L.L. and G.L. reviewed and approved the final report. All authors have read and approved the final manuscript. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com) Address for correspondence: Gang Liu, MD, Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No. 56 Nan Lishi Road, Beijing 100045, China. E-mail: [email protected]. The Pediatric Infectious Disease Journal: February 2021 - Volume 40 - Issue 2 - p 109-115 doi: 10.1097/INF.0000000000002933 Buy SDC Metrics Abstract Background: There are limit studies about pediatric brain abscess in China. The aim of this study was to analyze clinical characteristics and outcomes of pediatric brain abscess in recent years in China. Methods: The clinical information of children with brain abscess hospitalized in Beijing Children’s Hospital between January 1, 2007 and December 31, 2016 were retrospectively reviewed. Results: Ninety-four children were enrolled in this study. A Streptococcus milleri group (13.8%) was identified as the most common causative organisms, followed by Staphylococcus aureus (6.4%). The overall mortality was 21.6%, with 50.0% of deaths happening in the first week after diagnosis. Long-term outcomes of 74 patients were assessed with Glasgow Outcome Scale–Extended Pediatric Reversion: 50 patients with a score of 1–2 (favorable outcome) and 24 patients with a score of 3–8 (unfavorable outcome). Patients with multiple abscesses (P = 0.029) and intraventricular rupture of brain abscess/hydrocephalus (P = 0.024) had higher risk of unfavorable outcomes. Conclusions: Brain abscess is a serious disease with high mortality in children; more aggressive treatments should be considered in the first week of diagnosis because of high risk of death, and for patients with multiple brain abscesses and intraventricular rupture of brain abscess/hydrocephalus because of their higher risk of unfavorable. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.