Immunology and Host ResponseResistance to Antibiotics of Uropathogen Bacteria Isolated From Urine and Blood in Pediatric Cancer Patients A Single Center, 12-year StudyLandi, Francesca MD; Bandettini, Roberto MD; Rotulo, Gioacchino Andrea MD; Mesini, Alessio MD; Saffioti, Carolina MD; Amoroso, Loredana MD; Pierri, Filomena MD; Guardo, Daniela MD; Castagnola, Elio MDAuthor Information From the IRCCS Istituto Giannina Gaslini, Genova, Italy. Accepted for publication July 15, 2020. The authors have no conflicts of interest to disclose. F.L. participated in study design, data collection, analysis, and article preparation. R.B. participated in data collection and analysis. G.A.R. participated in data analysis. A.M. C.S., L.A. F.P., and D.G. participated in data collection and article review. E.C. participated in study design, data analysis, and article revision. All authors reviewed and approved the final version of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com). Address for correspondence: Elio Castagnola, MD, Infectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147 Genova, Italy. E-mail: [email protected]. The Pediatric Infectious Disease Journal: December 2020 - Volume 39 - Issue 12 - p 1106-1110 doi: 10.1097/INF.0000000000002854 Buy SDC Metrics Abstract Resistant pathogens have become a major healthcare problem in children with cancer, causing different kinds of infections such as the bloodstream ones, most common, and most frequently described and the urinary tract ones, of which less data are available. We analyzed and compared the proportions, and the trends of resistance in pathogens isolated from blood and urines in children with cancer followed in IRCCS Istituto Giannina Gaslini, Genova, Italy, from January 2007 to December 2018. Overall, 345 strains detected in urines and 282 in bloodstream infections were analyzed. Enterobacteriales were the most frequently isolated pathogens. During the study period in urines, there was a significant increase of resistance to ceftazidime, ciprofloxacin, piperacillin/tazobactam, and trimethoprim-sulfamethoxazole, but pathogens from blood were significantly more frequently resistant to amikacin, piperacillin/tazobactam, and combination therapy piperacillin/tazobactam+amikacin, even if with a decreasing trend during the study period. These data confirm the importance of surveillance of isolated microorganism and antibiotic resistance in cancer children. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.