Instructive CasesCongenital SARS-CoV-2 Infection in a Neonate With Severe Acute Respiratory SyndromeCorreia, Cátia R. MD*; Marçal, Mónica MD*; Vieira, Filipa MD*; Santos, Edmundo MD*; Novais, Cristina MD*; Maria, Ana Teresa MD*; Malveiro, Duarte MD*; Prior, Ana Rita MD*; Aguiar, Marta MD*; Salazar, Anabela MD*; Gouvêa Pinto, Constança MD*; Carvalho Rodrigues, Luís MD†; Pessanha, Maria Ana PhD†; Borges, Vítor PhD‡; Isidro, Joana MSc‡; Gomes, João Paulo PhD‡; Duarte, Sílvia MSc§; Vieira, Luís MSc§; Costa, Inês MSc¶; Alves, Maria João PhD‖; Calhau, Conceição PhD**; Guiomar, Raquel MSc¶; Tuna, Madalena Lopo MD*Author Information From the *Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de São Francisco Xavier, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal †Department of Clinical Pathology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal ‡Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal §Innovation and Technology Unit, Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal ¶National Reference Laboratory for Influenza and Other Respiratory Viruses, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal ‖National Reference Laboratory for Vector Borne Diseases, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal **Department of Nutrition and Metabolism, Nova Medical School, Universidade Nova de Lisboa, Lisbon, Portugal Accepted for publication September 17, 2020. The authors have no conflicts of interest to disclose. Address for correspondence: Cátia R. Correia, MD, Estrada do Forte do Alto do Duque, 1449-005 Lisboa, Portugal. E-mail: [email protected] The Pediatric Infectious Disease Journal: December 2020 - Volume 39 - Issue 12 - p e439-e443 doi: 10.1097/INF.0000000000002941 Buy Metrics Abstract Coronavirus disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is mainly transmitted through droplets, but other ways of transmission have been hypothesized. We report a case of vertical transmission of SARS-CoV-2 in a preterm born to an infected mother, confirmed by the presence of the virus in the neonatal blood, nasopharyngeal and oropharyngeal swabs collected in the first half an hour of life. The neonate presented with acute respiratory distress, similar to the findings in severely affected adults. This case highlights the importance of pregnancy, labor and neonatal period surveillance of affected mothers and their newborns. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.