Instructive CasesE. coli Monomicrobial Necrotizing Fasciitis in an Iron-Overloaded AdolescentNazir, Hanan PhD*,†; Al Yazidi, Laila FRACP‡; Mutani, Mohammed FRCS§; Zachariah, Mathew FRCP*Author Information From the *Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman †Department of Pediatrics, Alexandria Faculty Of Medicine, Alexandria, Egypt ‡Infectious Diseases Department §Orthopedic Department, Sultan Qaboos University Hospital, Muscat, Oman. Accepted for publication November 1, 2019. The authors have no funding or conflicts of interest to disclose. Address for correspondence: Hanan Fawzy Nazir, MBBCh, MM, PhD, Child Health Department, SQUH, Alkhoudh, Muscat 123, PO Box 38, Oman. E-mail: email@example.com. The Pediatric Infectious Disease Journal: April 2020 - Volume 39 - Issue 4 - p e40-e41 doi: 10.1097/INF.0000000000002548 Buy Metrics Abstract Escherichia coli is an extremely unusual cause of monomicrobial necrotizing fasciitis of the extremities in children. We report a transfusion-dependent adolescent boy with iron-overload secondary to congenital dyserythropoietic anemia who developed severe E. coli monomicrobial necrotizing fasciitis of the leg following a minor trauma. Combined surgical, antimicrobial and supportive care resulted in a good outcome. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.