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Pathology of Rotavirus-driven Multiple Organ Failure in a 16-month-old Boy

Tarris, Georges MD, MSc*,†; Belliot, Gaël PhD, MSc*,‡; Callier, Patrick PharmD, PhD, MSc§; Huet, Frédéric MD, PhD, MSc§; Martin, Laurent MD, PhD, MSc†,¶; de Rougemont, Alexis MD, PhD, MSc*,‡

The Pediatric Infectious Disease Journal: December 2019 - Volume 38 - Issue 12 - p e326–e328
doi: 10.1097/INF.0000000000002472
Immunology and Host Response
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Autopsy investigation of a fatal case of rotavirus severe acute gastroenteritis and multiple organ failure in a 16-month boy with previous intrauterine growth retardation showed colocalization of nonstructural and structural rotavirus proteins within viroplasms in nephrons. This case brings new insights into extraintestinal rotavirus infection and new clues to its abilities to bind to human histo-blood group antigens.

From the *National Reference Centre for Gastroenteritis Viruses, Laboratory of Virology, University Hospital of Dijon Bourgogne, Dijon, France

Department of Pathology, University Hospital of Dijon Bourgogne, Dijon, France

UMR PAM A 02.102 Procédés Alimentaires et Microbiologiques, Université de Bourgogne Franche-Comté/AgroSup Dijon, Dijon, France

§INSERM LNC UMR 1231, Équipe GAD, Université de Bourgogne Franche-Comté, Dijon, France

University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Dijon, France.

Accepted for publication August 9, 2019.

This research was funded by the Regional Council of Bourgogne—Franche-Comté, the “Fonds Européen de DEveloppement Régional (FEDER)” IGDA 2017-6200FEO001S01850.

The authors have no conflicts of interest to disclose.

The need for an Ethics Committee approval was waived, as examination by the Committee for the Protection of Persons Est-I declared the study as outside French Jardé’s field of law.

Address for correspondence: Pr. Alexis de Rougemont, CNR des virus des gastro-entérites, PBHU, CHU de Dijon, 2 rue Angélique Ducoudray, BP37013, 21070 Dijon cedex, France. E-mail: alexis.de-rougemont@u-bourgogne.fr.

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