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Utility of Surface and Blood Polymerase Chain Reaction Assays in Identifying Infants With Neonatal Herpes Simplex Virus Infection

Samies, Nicole DO*; Jariwala, Ravi MD; Boppana, Suresh MD*,‡; Pinninti, Swetha MD*

The Pediatric Infectious Disease Journal: November 2019 - Volume 38 - Issue 11 - p 1138–1140
doi: 10.1097/INF.0000000000002451
Maternal-Neonatal Reports
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Of 27 neonates with herpes simplex virus, DNAemia was observed in 100% with disseminated disease, 57% with central nervous system disease and 28% with skin, eye, mouth disease, suggesting DNAemia occurs frequently in these infants. Herpes simplex virus culture and polymerase chain reaction were performed on surface specimens from 13/27 infants, and ~50% tested positive only by polymerase chain reaction, suggesting the superiority of this technique.

From the *Division of Pediatric Infectious Diseases, Department of Pediatrics

Department of Internal Medicine

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.

Accepted for publication July 24, 2019.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Nicole Samies, DO Fellow, Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, CHB 308, 1600 6th Ave S, Birmingham, AL 35233. E-mail: nsamies@uabmc.edu.

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