Antimicrobial ReportsGlobal Divergence From World Health Organization Treatment Guidelines for Neonatal and Pediatric SepsisJackson, Charlotte PhD*; Hsia, Yingfen PhD*; Basmaci, Romain MD, PhD†,‡; Bielicki, Julia MD*,§; Heath, Paul T. FRCPCH*; Versporten, Ann MPH¶; Goossens, Herman PhD¶; Sharland, Mike MD*Author Information From the *Paediatric Infectious Diseases Research Group, Institute of Infection and Immunity, St George’s, University of London, London, United Kingdom †Service de Pédiatrie-Urgences, Hôpital Louis-Mourier, APHP, Colombes, France ‡INSERM, Infection, Antimicrobiens, Modélisation, Evolution (IAME), UMR1137, Université Paris Diderot - Sorbonne Paris Cité, Paris, France §Paediatric Pharmacology and Paediatric Infectious Diseases, University Children’s Hospital Basel, Basel, Switzerland ¶Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium. Accepted for publication June 12, 2019. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com). Address of correspondence: Charlotte Jackson, PhD, MRC CTU at UCL, 90 High Holborn, London WC1V 6LJ, United Kingdom. E-mail: [email protected]. The Pediatric Infectious Disease Journal: November 2019 - Volume 38 - Issue 11 - p 1104-1106 doi: 10.1097/INF.0000000000002433 Buy SDC Metrics Abstract We used data from 2 global point prevalence surveys of antibiotic prescribing to describe the treatment of sepsis in hospitalized neonates and children. One hundred eighty-five of 824 neonates (22.5%) and 9/786 children (1.1%) received a World Health Organization-recommended first-line treatment; of the remainder, 9/639 neonates (1.4%) and 102/777 children (13.1%) received a World Health Organization-recommended second-line treatment. Reasons for this low adherence to guidance should be explored. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.