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Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

Tabatabai, Julia MD*,†,‡; Fakhiri, Julia MSc*,§; Meyburg, Jochen MD; Linse, Kai-Philipp*,‡,§; Xu, Man PhD; Söderlund-Venermo, Maria PhD; Grimm, Dirk PhD*,‡,§,‖; Schnitzler, Paul PhD*

The Pediatric Infectious Disease Journal: September 2019 - Volume 38 - Issue 9 - p e219–e222
doi: 10.1097/INF.0000000000002354
Instructive Cases
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We report a case of lower respiratory tract infection with human bocavirus 1 (HboV1) in an immunodeficient 6-month-old boy leading to respiratory failure with fatal outcome. Polymerase chain reaction of serum/tracheal secretions revealed exceptionally high HboV1-DNA levels and immunoassays showed seroconversion indicating an acute primary HboV1 infection. All assays for other pathogens were negative, strongly suggesting that HboV1 was the causative agent in this case.

From the *Center for Infectious Diseases, Virology and

Center for Childhood and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

German Center for Infection Research (DZIF) Heidelberg, Germany

§BioQuant Center, University of Heidelberg, Heidelberg, Germany

Department of Virology, University of Helsinki, Helsinki, Finland

Cluster of Excellence CellNetworks, Heidelberg, Germany.

Accepted for publication March 7, 2019.

This study was funded in part by the Cystic Fibrosis Foundation (grant GRIMM15XX0) for J.F., K.-P.L. and D.G. K.-P.L. was supported by an MD stipend from the German Center for Infection Research (DZIF; BMBF). J.T. received a clinical leave stipend from DZIF. M.X. was funded by the China Scholarship Council and M.S-V. by the Sigrid Jusélius Foundation and the Life and Health Medical Association.

The authors have no conflicts of interest to disclose.

J.T. and P.S. were participated in study design. J.T., J.M. and P.S. were participated in clinical evaluation. J.F., K.-P.L. and M.X. were participated in laboratory testing. J.T., J.F., K.-P.L., M.S.-V., D.G. and P.S. were participated in data analysis and manuscript preparation. All authors reviewed and approved the final manuscript.

The study was approved by the Ethical Research Board of the University Hospital Heidelberg, Germany (S-547/2015). All samples and medical information included in this study were obtained during routine medical care.

Address for correspondence: Julia Tabatabai, MD. Center for Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg. E-mail: julia.tabatabai@med.uni-heidelberg.de.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.