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Strategic Trials to Define the Best Available Treatment for Neonatal and Pediatric Sepsis Caused by Carbapenem-resistant Organisms

Donà, Daniele MD, PhD*,†; Sharland, Mike MD*; Heath, Paul T. MD*; Folgori, Laura MD*,‡

The Pediatric Infectious Disease Journal: August 2019 - Volume 38 - Issue 8 - p 825–827
doi: 10.1097/INF.0000000000002381
Antimicrobial Reports

The optimal standard of care for carbapenem-resistant bloodstream infections in children is currently unknown. This systematic review, aiming to define the best available treatments to be compared with new antibiotics in clinical trials, clearly points out the paucity of available data. The simplification and a wider harmonization of study design are a global priority to inform the best strategies to treat these life-threatening infections in children.

From the *Paediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom

Division of Paediatric Infectious Diseases, Department for Woman and Child Health, University of Padua, Padua

Paediatric Infectious Disease Unit, Department of Paediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Accepted for publication April 19, 2019.

The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (

Address for correspondence: Laura Folgori, MD, St George’s University of London, Jenner Wing, Level 2, Room 2.215E, Cranmer Terrace, London SW17 0RE, United Kingdom. E-mail:

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