The optimal standard of care for carbapenem-resistant bloodstream infections in children is currently unknown. This systematic review, aiming to define the best available treatments to be compared with new antibiotics in clinical trials, clearly points out the paucity of available data. The simplification and a wider harmonization of study design are a global priority to inform the best strategies to treat these life-threatening infections in children.
From the *Paediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom
†Division of Paediatric Infectious Diseases, Department for Woman and Child Health, University of Padua, Padua
‡Paediatric Infectious Disease Unit, Department of Paediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy.
Accepted for publication April 19, 2019.
The authors have no funding or conflicts of interest to disclose.
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Address for correspondence: Laura Folgori, MD, St George’s University of London, Jenner Wing, Level 2, Room 2.215E, Cranmer Terrace, London SW17 0RE, United Kingdom. E-mail: lfolgori@sgul.ac.uk.
