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First Case Report of Intraventricular Tigecycline in a Neonate With Extensively Drug-resistant Acinetobacter baumannii Ventriculitis

Pratheep, Rathna MD*; Ray, Somosri MD*; Mukhopadhyay, Kanya MD, DM*; Gautam, Vikas PhD, MD; Shafiq, Nusrat MD, DM; Dutta, Sourabh PhD, MD*; Saini, Shiv Sajan MD, DM*; Bhatia, Anmol MD§

The Pediatric Infectious Disease Journal: August 2019 - Volume 38 - Issue 8 - p e172–e174
doi: 10.1097/INF.0000000000002348
Maternal-Neonatal Reports

Multidrug-resistant and extensively drug-resistant Acinetobacter baumannii infections have been increasing as a cause of healthcare-associated infections in the neonatal age group. In this report, we describe a 27-week, 1028 g, preterm neonate with extensively drug-resistant A. baumannii infection complicated by ventriculitis who did not respond to intravenous and intraventricular colistin but did respond after intraventricular tigecycline. This is the first case report describing the use of intraventricular tigecycline in a neonate with ventriculitis.

From the *Neonatology Unit, Department of Pediatrics

Department of Microbiology

Department of Pharmacology

§Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Accepted for publication March 26, 2019.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Kanya Mukhopadhyay, MD, DM, Neonatology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160 012, India. E-mail

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