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Successful Whole Genome Sequencing-guided Treatment of Mycoplasma hominis Ventriculitis in a Preterm Infant

Scaggs Huang, Felicia A. MD*; Mortensen, Joel PhD; Skoch, Jesse MD; Andersen, Heidi MD, MS*; Staat, Mary Allen MD, MPH*; Schaffzin, Joshua K. MD, PhD*; Haslam, David B. MD*

The Pediatric Infectious Disease Journal: July 2019 - Volume 38 - Issue 7 - p 749–751
doi: 10.1097/INF.0000000000002306
Translational Medicine Reports

We report a case of Mycoplasma hominis ventriculitis in a preterm neonate that was successfully identified with 16S ribosomal RNA sequencing and whole genome sequencing after failure to detect the pathogen with conventional diagnostic methods. The infant required doxycycline with subsequent clearance of the infection and no evidence of drug toxicity.

From the *Department of Pediatrics, Division of Pediatric Infectious Diseases

Department of Pathology and Laboratory Medicine

Department of Pediatrics, Division of Neurosurgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.

Accepted for publication February 2, 2019.

This work was supported by funding from Dr. Haslam’s Precision Metagenomic Core Laboratory.

H.A. receives funding from the NIH T32ES010957-14 training grant at the University of Cincinnati. The other authors have no conflicts of interest to disclose.

Address for correspondence: Felicia Scaggs Huang, MD, 3333 Burnet Ave MLC 7017, Cincinnati, OH 45229. E-mail:

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