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HIV-1 Drug Resistance and Virologic Outcomes Among Tanzanian Youth Living With HIV

Dow, Dorothy E., MD, MSc*,†,‡; Shayo, Aisa M., MMED; Cunningham, Coleen K., MD*,‡; Mmbaga, Blandina T., MD, PhD†,‡,§

The Pediatric Infectious Disease Journal: June 2019 - Volume 38 - Issue 6 - p 617–619
doi: 10.1097/INF.0000000000002288
HIV Reports
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Adolescents living with HIV tend to have poor adherence that often breeds HIV resistance mutations and virologic failure (VF). This study evaluated risk behavior, virologic outcomes and HIV resistance mutations in Tanzanian youth living with HIV. Participants were primarily perinatally infected and of mean age 16.7 years; among them 41.5% had VF. Those receiving first-line therapy demonstrated over 90% resistance to their current therapy.

From the *Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina

Kilimanjaro Christian Medical Centre, Moshi, Tanzania

Duke Global Health Institute, Duke University, Durham, North Carolina

§Kilimanjaro Christian Research Laboratory, Moshi, Tanzania.

Accepted for publication January 11, 2019.

Supported by Duke University Center for AIDS Research (CFAR), an NIH-funded program P30 AI064518, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) training Grant T32 HD060558, NIH Research Training Grant R25 TW009337 and IRSDA K01 TW-009985 funded by the Fogarty International Center and the National Institute of Mental Health.

The authors have no conflicts of interest to disclose.

Address for correspondence: Dorothy E. Dow, MD, MSc, Duke University Medical Center, Box 3499, Durham, NC 27710. E-mail: dorothy.dow@duke.edu.

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