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Report of Resistant Varicella Zoster Infection Treated With Donor Lymphocyte Infusion in a Pediatric Oncology Patient

Cooper, Katherine, MBChB, MRCPCH*; Makin, Guy, BM, BCh, PhD, MRCP, FRCPCH; Davies, Emma, MSc; Turner, Andrew, MBChB, FRCPath; Hiwarkar, Prashant, MBBS, MD, PhD, FRCPCH§; Wynn, Robert, BA, MB BChir, MD, MRCP, FRCPath§

The Pediatric Infectious Disease Journal: May 2019 - Volume 38 - Issue 5 - p 513–515
doi: 10.1097/INF.0000000000002252
Immunology Reports

We report an 8-year-old boy with disseminated, life-threatening, drug treatment-resistant varicella zoster infection occurring during standard treatment for neuroblastoma in whom viral clearance and cure was effected by donor Lymphocyte infusion from his HLA (Human leukocyte antigen)-identical twin sibling.

From the *Department of Paediatric Oncology and Haematology, Alder Hey Children’s Hospital, Liverpool, United Kingdom

Department of Paediatric Oncology, Royal Manchester Children’s Hospital

Department of Clinical Virology, Manchester Royal Infirmary

§Department of Paediatric Blood and Marrow Transplant, Royal Manchester Children’s Hospital, Manchester, United Kingdom.

Accepted for publication October 26, 2018.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Katherine Cooper, MBChB, MRCPCH, Department of Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, United Kingdom. E-mail:

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