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Use of Triple Combination Antiretroviral Therapy With Raltegravir as Empiric HIV Therapy in the High-risk HIV-exposed Newborn

Trahan, Marie-Julie, MD*; Lamarre, Valérie, MD†,‡,§; Metras, Marie-Elaine, PharmD, MSc; Kakkar, Fatima, MD, MPH†,‡,§

The Pediatric Infectious Disease Journal: April 2019 - Volume 38 - Issue 4 - p 410–412
doi: 10.1097/INF.0000000000002180
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The recent approval of raltegravir granules for suspension in the newborn population offers a new option for the antiretroviral prophylaxis of newborns for the prevention of perinatal transmission. However, there are little data on its use in preterm infants, nor on outcomes following its use as empiric HIV therapy for newborns subsequently found to be infected. We describe here the use of RAL granules for suspension in these cases.

From the *Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada

Université de Montréal, Department of Pediatrics, Montreal, Quebec, Canada

CHU Sainte-Justine, Division of Infectious Diseases, Montreal, Quebec, Canada

§CHU Sainte-Justine Research Center, Centre Maternel et Infantile sur le SIDA, Montreal, Canada

CHU Sainte Justine, Department of Pharmacy, Montreal, Quebec, Canada

Accepted for publication August 7, 2018.

Supported, in part, by a Fonds de Recherche Santé (FRQS) clinician investigator grant to F.K.

The authors have no conflicts of interest to disclose.

Address for correspondence: Fatima Kakkar, MD, Division of Pediatric Infectious Diseases, CHU Sainte-Justine, 3175 Côte Sainte-Catherine, Montreal, Quebec, Canada. E-mail: fatima.kakkar@umontreal.ca.

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