We report on the successful treatment of a South African infant with hepatitis B virus (HBV)–induced acute liver failure using lamivudine with no evidence of clinical resistance. Perinatal HBV transmission occurred despite timely HBV vaccination at 6, 10 and 14 weeks, as per South African vaccination schedule, highlighting the need to introduce the birth-dose HBV vaccine in South Africa.
From the *Division of Medical Virology, Department of Pathology
†Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa
‡Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Accepted for publication March 8, 2018.
The authors have no funding or conflicts of interest to disclose.
Address for correspondence: Etienne De La Rey Nel, MMed, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, 2nd Floor, Clinical Building, Francie van Zijl Drive, Tygerberg, Cape Town 7505, South Africa. E-mail: email@example.com.