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Successful Treatment of a South African Pediatric Case of Acute Liver Failure Caused by Perinatal Transmission of Hepatitis B

Chotun, Nafiisah, MSc*; Strobele, Silvia, MMed; Maponga, Tongai Gibson, PhD*; Andersson, Monique Ingrid, MD*,‡; Nel, Etienne De La Rey, MMed

The Pediatric Infectious Disease Journal: March 2019 - Volume 38 - Issue 3 - p e51–e53
doi: 10.1097/INF.0000000000002054
Maternal-Neonatal Reports
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We report on the successful treatment of a South African infant with hepatitis B virus (HBV)–induced acute liver failure using lamivudine with no evidence of clinical resistance. Perinatal HBV transmission occurred despite timely HBV vaccination at 6, 10 and 14 weeks, as per South African vaccination schedule, highlighting the need to introduce the birth-dose HBV vaccine in South Africa.

From the *Division of Medical Virology, Department of Pathology

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Accepted for publication March 8, 2018.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Etienne De La Rey Nel, MMed, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, 2nd Floor, Clinical Building, Francie van Zijl Drive, Tygerberg, Cape Town 7505, South Africa. E-mail: edn@sun.ac.za.

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