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Second-trimester Ultrasound and Neuropathologic Findings in Congenital Zika Virus Infection

Ho, Cheng-Ying, MD*; Castillo, Nicolas, MD; Encinales, Liliana, MD; Porras, Alexandra, PhD§; Mendoza, Alejandro Rico, PhD§; Lynch, Rebecca, PhD; Nemirovsky, Amy, BA*; Mantus, Grace, BS; DeBiasi, Roberta L., MD‖,**,††; Bethony, Jeffrey M., PhD; Simon, Gary L., MD††; Chang, Aileen Y., MD††

The Pediatric Infectious Disease Journal: December 2018 - Volume 37 - Issue 12 - p 1290–1293
doi: 10.1097/INF.0000000000002080
Maternal-Neonatal Reports

Zika virus is a mosquito-borne virus that causes congenital Zika syndrome, characterized by microcephaly and other fetal brain anomalies. This case report presents a case of Zika virus–related fetal brain anomalies including pathologic evidence of cerebral neuronal apoptosis and macrophage infiltrates and intracerebral calcification, ventriculomegaly and corpus callosum dysgenesis detected by ultrasound at 18 weeks of pregnancy.

From the *Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland

Department of Maternal Fetal Health

Department of Medicine, Allied Research Society LLC, Baranquilla, Atlántico, Colombia

§Grupo de Medicina Comunitaria, Universidad El Bosque, Bogotá, Colombia

Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia

Division of Pediatric Infectious Diseases, Children’s National Health System, Washington District of Columbia

**Department of Pediatrics

††Department of Medicine, The George Washington University, Washington, District of Columbia.

Accepted for publication January 8, 2018.

Supported by the National Institutes of Health U19 AI131130 (awarded to C.-Y.H.) and UL1TR001876 and KL2TR001877 from the NIH National Center for Advancing Translational Sciences (awarded to A.Y.C.). Its contents are solely the responsibility of the authors and do not necessary represent the official views of the National Center for Advancing Translational Science or the National Institute of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

The authors have no conflicts of interest to disclose.

C.-Y.H. and N.C. contributed equally to this work.

Address for correspondence: Aileen Y. Chang, MD, MSPH, George Washington University, 2150 Pennsylvania Ave 5–416, Washington, DC 20037. E-mail:

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.