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Is There a Higher Risk of Mother-to-child Transmission of HIV Among Pregnant Women With Perinatal HIV Infection?

Goodenough, Christopher J., MD*; Patel, Kunjal, DSc; Van Dyke, Russell B., MD for the Pediatric HIV/AIDS Cohort Study (PHACS)

The Pediatric Infectious Disease Journal: December 2018 - Volume 37 - Issue 12 - p 1267–1270
doi: 10.1097/INF.0000000000002084
HIV Reports

Cases of mother-to-child-transmission in the Surveillance Monitoring of ART Toxicities Study of Pediatric HIV/AIDS Cohort Study were identified from 2007 to 2015. Among 2123 births, 9 infants were HIV infected, giving a mother-to-child-transmission rate of 0.5% (95% confidence interval: 0.3%–1.0%). Mothers with perinatal HIV infections had a higher mother-to-child-transmission rate (1.1%; 95% confidence interval: 0.3%–4.3%) than mothers without perinatal HIV infections (0.4%; 95% confidence interval: 0.2%–1.0%), associated with a greater likelihood of detectable viral load at delivery.

From the *University of Texas Health Science Center at Houston, Houston, Texas

Department of Epidemiology, Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, Boston, Massachusetts

Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana.

Accepted for publication March 15, 2018.

This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse, the National Institute of Allergy and Infectious Diseases, the Office of AIDS Research, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on Deafness and Other Communication Disorders, the National Heart Lung and Blood Institute, the National Institute of Dental and Craniofacial Research and the National Institute on Alcohol Abuse and Alcoholism through cooperative agreements with the Harvard T.H. Chan School of Public Health (HD052102; Principal Investigator: George Seage; Project Director: Julie Alperen) and the Tulane University School of Medicine (HD052104; Principal Investigator: Russell Van Dyke; Co-Principal Investigator: Kenneth Rich; Project Director: Patrick Davis). Data management services were provided by Frontier Science and Technology Research Foundation (Principal Investigator: Suzanne Siminski), and regulatory services and logistical support were provided by Westat, Inc (Principal Investigator: Julie Davidson). The conclusions and opinions expressed in this article are those of the authors and do not necessarily reflect those of the National Institutes of Health or U.S. Department of Health and Human Services.

The authors have no conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Christopher J. Goodenough, MD, MPH, Department of Surgery, University of Texas Health Sciences Center, 6431 Fannin Street, MSB 4.331, Houston, TX 77030. E-mail: christopher.j.goodenough@uth.tmc.edu.

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