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Identification of Amino Acid Substitutions Within the VP7 Genes of G2 Rotavirus Strains in Ghana

Damanka, Susan A., PhD; Agbemabiese, Chantal A., PhD; Lartey, Belinda L., MPhil; Dennis, Francis E., PhD; Asamoah, Frederick K., BSc; Adiku, Theophilus K., PhD; Enweronu-Laryea, Christabel C., MRCPCH; Sagoe, Kwamena W., PhD; Ofori, Michael F., PhD; Armah, George E., PhD

The Pediatric Infectious Disease Journal: November 2018 - Volume 37 - Issue 11 - p 1172–1174
doi: 10.1097/INF.0000000000002037
Pathogenesis and Host Response

We used the dideoxynucleotide chain termination method to determine the strains of nine non-typeable rotavirus enzyme immunoassay–positive samples, which were identified as G2. We detected nucleotide changes in the primer-binding region and amino acid substitutions within the VP7 protein of the G2 rotavirus strains. Genotyping primers need to be updated regularly.

From the Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Accepted for publication December 19, 2017

The authors have no funding or conflicts of interest to disclose.

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Address for correspondence: Susan Damanka, PhD, Department of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, PO Box LG 581, Legon, Accra, Ghana. E-mail: sdamanka@noguchi.ug.edu.gh.

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