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Symptomatic Cytomegalovirus Infections in the First Year of Life: When Is Antiviral Therapy Conceived to Be Justified?

Schuster, Katharina MD; Goelz, Rangmar MD; Speckmann, Carsten MD; Henneke, Philipp MD

The Pediatric Infectious Disease Journal: February 2017 - Volume 36 - Issue 2 - p 224–227
doi: 10.1097/INF.0000000000001407
Instructive Cases

All infants treated with antiviral medication for symptomatic congenital (diagnosis <3 weeks) and probably postnatal (>3 weeks) cytomegalovirus infection were characterized with the help of a survey covering all German Pediatric hospitals between 2012 and 2013. We found that >50% of infants treated for cytomegalovirus were classified as probably postnatal cytomegalovirus infection, which was associated with preterm birth and underlying diseases of the immune system, heart or lung.

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From the *Department of Pediatrics and Adolescent Medicine, Medical Center – University of Freiburg, Freiburg, Germany; Department of Neonatology, University Children’s Hospital Tuebingen, 72076 Tuebingen, Germany; and Center for Chronic Immunodeficiency, Medical Center – University of Freiburg, Freiburg, Germany.

Accepted for publication July 21, 2016.

C.S. and P.H. contributed equally to this study.

Supported by a grant from the German Federal Ministry of Education and Research (Grant 01EO0803 to P.H.).

The authors have no conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (

Address for correspondence: Philipp Henneke, MD, Pediatric Infectious Disease & Rheumatology, Center for Chronic Immundeficiency (CCI), Center for Pediatrics & Adolescent Medicine, University Medical Center Freiburg, Breisacherstr. 115, 79106 Freiburg, Germany. E-mail:

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