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Children Hospitalized With Varicella in Denmark

Sensitivity of the National Patient Register

Glode Helmuth, Ida MD; Broccia, Marcella Ditte MD; Glenthøj, Jonathan Peter MD; Harder, Katja MD, PhD; Jensen, Lise MD; von Linstow, Marie-Louise MD, PhD; Poulsen, Anja MD, PhD; Mølbak, Kåre MD, DMSc

The Pediatric Infectious Disease Journal: January 2017 - Volume 36 - Issue 1 - p 31–35
doi: 10.1097/INF.0000000000001347
Original Studies

Background: Varicella, common in childhood and most often self-limiting, may cause complications including bacterial superinfection, pneumonia and encephalitis. Universal childhood varicella vaccination has been introduced in several countries, but is controversial in Europe. In Denmark, varicella is not part of the national immunization program and there is no national surveillance of varicella. The primary aim of the study was to describe the epidemiology and clinical characteristics of children hospitalized with varicella in Denmark. The secondary aim was to validate the sensitivity and completeness of the Danish National Patient Register.

Methods: Active surveillance of children hospitalized with varicella was carried out at 4 pediatric departments. In the Danish National Patient Register, we identified all children discharged with an International Classification of Diseases, 10th revision code of varicella from the 4 departments. We used a capture–recapture analysis to estimate the “true” number of hospitalized children with varicella.

Results: By active surveillance, we identified 86 children eligible for clinical description. In 87% of cases, the children were 0–4 years of age. Complications were identified in 69% of patients, including 1 child with postvaricella cerebral angiopathy. In the National Patient register (NPR), we identified 125 children with a discharge diagnosis of varicella. By capture–recapture analysis, the sensitivity of the NPR was estimated to be 74%.

Conclusions: Varicella can cause serious complications including cerebral angiopathy in children in Denmark. The NPR will be a useful tool for estimating hospitalization incidence, but will underestimate the true number of hospitalizations.

From the *Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark; Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark; Department of Pediatrics, Hvidovre Hospital, Denmark; §Department of Pediatrics, Nordsjællands Hospital, Denmark; and Department of Pediatrics, Zealand University Hospital, Roskilde, Denmark.

Accepted for publication June 16, 2016.

Ida Glode Helmuth has received research funding for her PhD study on varicella epidemiology through an unrestricted grant to her employer, the Department of Pediatrics and Adolescent Medicine at Rigshospitalet, from GlaxoSmith-Kline. The other authors have no conflicts of interest to disclose.

Address for correspondence: Ida Glode Helmuth, MD, Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Department of Infectious Disease Epidemiology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark. E-mail:

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