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Ten-Year Study of Acute Otitis Media in Rochester, NY

Pichichero, Michael E. MD

The Pediatric Infectious Disease Journal: September 2016 - Volume 35 - Issue 9 - p 1027–1032
doi: 10.1097/INF.0000000000001216
Review Articles

This review summarizes a prospective, longitudinal 10-year study in Rochester, NY, involving 760 children where virtually all clinically diagnosed acute otitis media (AOM) was confirmed by bacterial culture of middle ear fluid. This review describes detection of otopathogens in middle ear fluid, nasopharyngeal (NP) otopathogen colonization patterns, AOM risk factor analysis, biomarkers of AOM and antibody responses to NP colonization by otopathogens. After licensure of PCV13, there was an immediate drop in AOM caused by Streptococcus pneumoniae (Spn) vaccine serotypes and shortly thereafer an increase in nonvaccine types 16, 21 and 35B. When NP co-colonization occurred, nontypeable Haemophilus influenzae (NTHi) predominated over Spn to cause AOM, and NTHi and Spn both predominated over Moraxella catarrhalis. Transcriptome analysis of peripheral blood mononuclear cells identified unique signatures for NTHi AOM compared with Spn AOM. Elevation of 3 cytokines in serum (S100A12, intercellular adhesion molecule 1 and interleukin 10) accurately predicted the presence and recovery from AOM and the likely otopathogen. NP colonization was an immunizing event.

From the Center for Infectious Disease and Vaccine Immunobiology, Rochester General Hospital Research Institute, Rochester, New York.

Accepted for publication February 16, 2016.

This study was supported by NIH NIDCD R01 DC08671.

The authors have no conflicts of interest to disclose.

Contributors of this study are from Rochester General Hospital Research Institute: Drs. Qingfu Xu, Ravinder Kaur, Nadeem Khan, Naveen Surendran, Saleem Basha, Sharad Sharma, David Verhoeven, Dabin Ren, Matthew Morris and Robert Zagursky, and administrative assistant Kari Pedreira; from Legacy Pediatrics: Dr. Janet Casey and her staff along with the families who have participated in this research and from University of Rochester: Drs. Tim Mosmann, Alexandra Livingstone and Anthony Almudevar.

Address for correspondence: Michael E. Pichichero, MD, Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621. E-mail:

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