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Voriconazole Concentrations in Cerebrospinal Fluid During Prophylactic Use in Children with Acute Myelogenous Leukemia

Kobayashi, Ryoji MD, PhD; Sano, Hirozumi MD; Kishimoto, Kenji MD; Suzuki, Daisuke MD, PhD; Yasuda, Kazue MD, PhD; Kobayashi, Kunihiko MD, PhD

The Pediatric Infectious Disease Journal: March 2016 - Volume 35 - Issue 3 - p 297–298
doi: 10.1097/INF.0000000000001012
Antimicrobial Reports
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We report analysis of voriconazole (VRCZ) concentration of cerebrospinal fluid (CSF) during prophylactic use in children and adolescents with acute myelogenous leukemia. The median CSF/plasma ratio was 0.57 (range, 0.35–1.04). There was a significant positive correlation between the VRCZ concentrations in CSF and plasma. The CSF/blood ratio negatively correlated with age, body weight and VRCZ concentration in plasma and CSF. VRCZ is more highly transferred to CSF at low plasma concentrations, and the rate is lower at high plasma concentrations. The exact mechanism of VRCZ penetration though blood−brain barrier is not known.

Supplemental Digital Content is available in the text.

From the Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan.

Accepted for publication June 27, 2015.

The authors have no conflicts of interest or funding to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Ryoji Kobayashi MD, PhD, Department of Pediatrics, Sapporo Hokuyu Hospital, Higashi-Sapporo 6-6, Shiroishiku Sapporo, Hokkaido 003-0006, Japan. E-mail: r-koba@jacls.jp.

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