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A Reappraisal of the Minimum Duration of Antibiotic Treatment Before Approval of Return to School for Children With Streptococcal Pharyngitis

Schwartz, Richard H. MD*†; Kim, Danica BA; Martin, Michael MD*†; Pichichero, Michael E. MD§¶

The Pediatric Infectious Disease Journal: December 2015 - Volume 34 - Issue 12 - p 1302–1304
doi: 10.1097/INF.0000000000000883
Original Studies

Objective: To determine whether a single dose of amoxicillin administered to a symptomatic child with confirmed strep throat might allow the child to return to school as little as 12 hours later.

Methods: We enrolled 111 evaluable children with sore throat plus a positive streptococcal rapid antigen detection test (RADT) as well as a positive result for group A Streptococci (GAS). After throat swab specimens were obtained, all participants received a single dose of amoxicillin (50 mg/kg). Twelve to 23 hours after the first dose of amoxicillin, all participants returned in the morning of day 2 for a second throat swab specimen. At the day 2 visit, a nurse or medical assistant obtained an interval history, tympanic membrane temperature, and a pediatrician or nurse practitioner examined the oropharynx.

Results: On the morning of day 2, only 10 of 111 participants continued to have a positive RADT result, confirmed by overnight throat culture. GAS were not detectable on the day 2 throat specimen by RADT and also by culture in 91% of the study participants (confidence interval: 86–96%). Seven of 10 failures had a marked decrease in number of β-hemolytic colonies, which were 3+ to 4+ on the initial overnight culture plate and decreased to 1+ on the follow-up (obtained on day 2) throat culture plate. Two participants continued to have 3+ or 4+ GAS after incubation of the second throat culture specimen.

Conclusions: Even in the late afternoon, a full dose of amoxicillin (50 mg/kg) administered after notification of positive RADT results for GAS resulted in nondetection of GAS in 91% of children the next morning. All children treated with amoxicillin for “strep throat” by 5 PM of day 1 may, if afebrile and improved, attend school on day 2.

From the *Department of Pediatrics, Inova Children’s Hospital, Falls Church, Virginia; Advanced Pediatrics, Vienna, Virginia; Department of Anesthesiology, Columbia University School of Medicine, New York, New York; §Research Institute, Rochester General Hospital, Center for Infectious Disease and Immunology, Rochester, New York; and Legacy Pediatrics, Rochester, New York.

Accepted for publication August 17, 2015.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Richard H. Schwartz, MD, Department of Pediatrics, Inova Children’s Hospital, Falls Church, 100 East St. SE, Suite 301, Vienna, VA 22180. E-mail:

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.