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Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin–Tazobactam in Children

Patel, Aesha MD*; Mao, Kuo-Rei RPh; McNeil, J. Chase MD*; Kaplan, Sheldon L. MD*; Vallejo, Jesus G. MD*

The Pediatric Infectious Disease Journal: August 2015 - Volume 34 - Issue 8 - p 849–850
doi: 10.1097/INF.0000000000000748
Antimicrobial Reports

Piperacillin–tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin–tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin–tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.

From the *Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, Texas; and Department of Pharmacy, Texas Children’s Hospital, Houston, Texas.

Accepted for publication January 11, 2015.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Jesus G. Vallejo, MD, Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, 1102 Bates Avenue, Suite 1150, Houston, TX 77030. E-mail:

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