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Importance of Enhanced Surveillance for Prevention of Pertussis in Children

Domínguez, Angela MD, PhD*†; Godoy, Pere MD, PhD†‡; Toledo, Diana MSc*†; Soldevila, Núria BSc*†; García-Cenoz, Manuel MD, PhD, MPH†§; Farrús, Gloria BSc; Crespo, Inma MSc*†; Caylà, Joan A. MD, PhD†¶; Sala, Maria Rosa MD; Camps, Neus MD; Barrabeig, Irene MD; Alvarez, Josep MDfor the Working Group for the Study of Pertussis in Catalonia and Navarre (Spain)


In the article on page 729, volume 34, issue 7, the funding statement was incomplete. The funding statement should also include the following “This study was funded by founds from FEDER.”

The Pediatric Infectious Disease Journal. 34(9):1043, September 2015.

The Pediatric Infectious Disease Journal: July 2015 - Volume 34 - Issue 7 - p 729–733
doi: 10.1097/INF.0000000000000708
Original Studies

Background: Bordetella pertussis infection causes considerable morbidity, even in countries with high vaccination coverage. Surveillance of pertussis is usually passive and based on mandatory reporting. We assessed the epidemiologic and clinical characteristics of pertussis cases detected by passive or enhanced surveillance.

Methods: A prospective population-based study was carried out from January 2012 to December 2013 in Catalonia and Navarre, 2 Spanish regions with a total population of 8.2 million. For each confirmed case, variables of age, sex, clinical symptoms, laboratory results and vaccination status were investigated. Associations between the variables studied and the type of surveillance were assessed by odds ratio (OR) and its 95% confidence interval (CI). Logistic regression was used to estimate adjusted OR (aOR).

Results: In children <18 years of age, passive surveillance was the most important source of detection (95.7% in <1 year). In children 5–10 years of age, passive surveillance detected 67.5% of cases. In those ≥18 years, enhanced surveillance was the most frequent source of case detection (82.5%). Inspiratory whoop (aOR: 1.94; 95% CI: 1.40–2.70), apnea (aOR: 1.92; 95% CI: 1.28–2.87) and posttussive vomiting (aOR: 1.43; 95% CI: 1.04–1.96) were symptoms included in the clinical case definition that were associated with passive surveillance.

Conclusions: Underreporting of symptomatic cases is important not only in adults, but also in children >1 year of age and suggests that providing clinics with free, fast laboratory diagnostic tests, together with enhanced surveillance of family contacts of any age is necessary to better determine existing cases. Enhanced surveillance may be helpful to better understand transmission patterns in the family and in the community.

From the *Departament de Salut Pública, Universitat de Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Agència de Salut Pública de Catalunya, Barcelona, Spain; §Instituto de Salud Pública de Navarra, Pamplona, Spain; and Agència de Salut Pública de Barcelona, Barcelona, Spain.

Accepted for publication March 22, 2015.

This study was supported by the Ministry of Science and Innovation, Institute of Health Carlos III (Project PI11/02557) and the Catalan Agency for the Management of Grants for University Research (AGAUR Grant number 2014/SGR 1403). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Angela Dominguez, MD, PhD, Departament de Salut Pública, Universitat de Barcelona, c/Casanova 143, 08036 Barcelona, Spain. E-mail:

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