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Apnea Induced by Respiratory Syncytial Virus Infection is not Associated with Viral Invasion of the Central Nervous System

Erez, Daniella Levy MD*; Yarden-Bilavsky, Havatzelet MD†‡; Mendelson, Ella PhD§; Yuhas, Yael PhD; Ashkenazi, Shai MD†‡; Nahum, Elhanan MD‡‖; Berent, Eva BSc; Hindiyeh, Musa PhD§; Bilavsky, Efraim MD*‡

The Pediatric Infectious Disease Journal: August 2014 - Volume 33 - Issue 8 - p 880–881
doi: 10.1097/INF.0000000000000311
Brief Reports

We aimed to study whether direct central nervous system invasion is responsible for the neurologic manifestations seen in hospitalized infants with respiratory syncytial virus (RSV) infection. Cerebrospinal fluid from infants with RSV infection was tested for the detection of the following respiratory RNA viruses: RSV, influenza A and B, pandemic influenza H1N1, Parainfluenza-3, human metapneumovirus, adenovirus, parechovirus and enterovirus. All children tested negative for the presence of viral material in the cerebrospinal fluid. Our results support the notion that the mechanism of RSV-induced neurologic manifestations, including apnea, is not direct central nervous system invasion.

From the *Departments of Pediatrics C; Departments of Pediatrics A, Schneider Children’s Medical Center, Petach Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; §Central Virology Laboratory, Public Health Services, Israel Ministry of Health, Tel Hashomer; Laboratory of Infectious Diseases, Felsenstein Medical Research Center; and Pediatric Intensive Care Unit, Schneider Children’s Medical Center, Petach Tikva, Israel.

Accepted for publication February 11, 2014.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Daniella Levy Erez, MD, Department of Pediatrics C Schneider Children’s Medical Center, 14 Kaplan Street, Petach Tikva 49202, Israel. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.