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Acquired Drug Resistance During Inadequate Therapy in A Young Child with Tuberculosis

Garcia-Prats, Anthony J. MD*; Willemse, Marianne MB, ChB; Seifart, Heiner I. PhD; Jordaan, Annemie M. Med Tech§; Werely, Cedric J. PhD§; Donald, Peter R. MD*; Schaaf, H. Simon MMed (Paed), MD (Paed)

The Pediatric Infectious Disease Journal: August 2014 - Volume 33 - Issue 8 - p 883–885
doi: 10.1097/INF.0000000000000336
Brief Reports

Drug resistance in children with tuberculosis is usually primary (transmitted); however, resistance acquisition during treatment is possible. We describe a child with tuberculosis who acquired drug resistance while receiving directly observed but inadequate first-line therapy and the programmatic and clinical factors that may have contributed to resistance acquisition.

Supplemental Digital Content is available in the text.

From the *Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg; Brooklyn Hospital for Chest Diseases, Cape Town; Division of Pharmacology; §Division of Molecular Biology and Human Genetics, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for Molecular and Cellular Biology, Stellenbosch University; and Tygerberg Children’s Hospital, Tygerberg, South Africa.

Accepted for publication March 5, 2014.

The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (

Address for correspondence: Anthony J. Garcia-Prats, MD, Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Clinical Building, Room 0085, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg, South Africa. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.