Respiratory viruses are important pediatric pathogens with pronounced seasonal patterns of circulation. Various hypotheses have been put forth to explain the seasonality of these infections, many involving environmental factors. This review summarizes the effect of temperature on the epidemicity of respiratory viruses, with an emphasis on epidemiological findings from large-scale metanalyses, laboratory-derived data using animal models and possible mechanisms to account for viral seasonality.
From the *Department of Microbiology; and †Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine, Mount Sinai, New York, NY.
Accepted for publication November 14, 2013.
The authors have no funding or conflicts of interest to disclose.
Address for correspondence: Nicole M. Bouvier, MD, Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. E-mail: Nicole.Bouvier@mountsinai.org.