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Prospective Cohort Study Comparing Seasonal and H1N1(2009) Pandemic Influenza Virus Illnesses in HIV-infected Children During 2009

Madhi, Shabir A. MBBCh, FCPaeds, PhD*†‡; Kuwanda, Locadiah MSc†‡; Venter, Marietjie PhD*; Violari, Avy FCPaeds§

The Pediatric Infectious Disease Journal: February 2014 - Volume 33 - Issue 2 - p 174–176
doi: 10.1097/INF.0b013e3182a73ebb
HIV Reports

A cohort of 410 young HIV-infected children was prospectively investigated for seasonal and A(H1N1p)2009 influenza virus illness during 2009. The incidence of confirmed illness due to seasonal influenza was 3-fold greater than A(H1N1p)2009 (0.7 vs. 0.2 per 100 child-weeks, respectively; P = 0.0001), and the clinical presentations were similar. Illnesses due to seasonal and A(H1N1p)2009 influenza were self-limiting without neuraminidase inhibitor therapy.

From the *National Institute of Communicable Diseases—Division of National Health Laboratory Service; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases; Medical Research Council: Respiratory and Meningeal Pathogens Research Unit; and §Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.

Accepted for publication May 8, 2013.

The study was funded in part through an unrestricted grant from Secure the Future Fund who did not have any input on study design, data analysis or write-up of the article. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Shabir A. Madhi, MBBCh, FCPaeds, PhD, National Institute for Communicable Diseases—A Division of National Health Laboratory Service, 1 Modderfontein Road, Sandrigham, 2131 Johannesburg, South Africa. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.