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Revisiting Pneumonia and Exposure Status in Infants Born to HIV-infected Mothers

Izadnegahdar, Rasa MPH, MD*; Fox, Matthew P. MPH, DSc*†; Jeena, Prakash MB ChB, FCP; Qazi, Shamim A. MBBS, DCH, MSc, MD§; Thea, Donald M. MSc, MD

The Pediatric Infectious Disease Journal: January 2014 - Volume 33 - Issue 1 - p 70–72
doi: 10.1097/INF.0b013e31829f0ade
HIV Reports

HIV-exposed uninfected infants are an increasing population. Past analyses have often categorized these infants as uninfected leading to inaccurate conclusions. We present a HIV exposure, rather than infection, based reanalysis of treatment failure among children with pneumonia to show that failure odds among HIV-exposed uninfected infants are intermediate between their unexposed and infected counterparts. Additional prospective studies aimed at better understanding this population are needed.

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From the *Center for Global Health and Development, Boston University; Department of Epidemiology, Boston University School of Public Health, Boston, MA; Pediatrics Department, N. Mandela School of Medicine, University of Kwazulu-Natal, Durban, South Africa; §Department of Maternal Newborn Child and Adolescent Health, World Health Organization, Geneva, Switzerland; and Department of International Health, Boston University School of Public Health, Boston, MA.

Accepted for publication May 10, 2013.

M.P.F. was supported by the National Institute of Allergy and Infectious Diseases (NIAID) under Award Number K01AI083097. The NIAID and USAID had no role in study design, data collection and analysis, decision to publish or preparation of the article. The content is solely the responsibility of the authors and does not necessarily represent the official views of WHO, the NIAID, the National Institutes of Health or other parties.

Supported by World Health Organization, USAID and NIAID.

S.A.Q. is a medical officer in the Department of Child and Adolescent Health and Development, WHO. The authors have no other funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (

Address for correspondence: Rasa Izadnegahdar, MPH, MD, Center for Global Health and Development, Boston University, 801 Massachusetts Avenue, 3rd Floor, Boston, MA 02118. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.