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Mycobacterium szulgai Chronic Multifocal Osteomyelitis in an Adolescent With Inherited STAT1 Deficiency

Shamriz, Oded MD*; Engelhard, Dan MD†‡; Rajs, Andrea Psorn MD§; Kaidar-Shwartz, Hasia PhD; Casanova, Jean-Laurent MD, PhD; Averbuch, Diana MD*†

The Pediatric Infectious Disease Journal: December 2013 - Volume 32 - Issue 12 - p 1345–1347
doi: 10.1097/01.inf.0000437067.43859.4c
Immunology Reports

We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.

From the *Department of Pediatrics; Pediatric Infectious Diseases Unit, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel; School of Primary Health Care, Monash University, Melbourne, Victoria, Australia; §Department of Microbiology, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem; National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel; and St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY

The authors have no funding and conflicts of interest to disclose.

Address for correspondence: Diana Averbuch, MD, Kiryat Hadassah, Pediatric Infectious Diseases Unit, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel. E-mail:,

© 2013 by Lippincott Williams & Wilkins, Inc.