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Tenofovir-induced Renal Tubular Dysfunction in Vertically HIV-infected Patients Associated With Polymorphisms in ABCC2, ABCC4 and ABCC10 Genes

Giacomet, Vania MD*; Cattaneo, Dario PhD†‡; Viganò, Alessandra MD*; Nannini, Pilar MD*; Manfredini, Valeria MD*; Ramponi, Giulia MD*; Clementi, Emilio MD†‡§; Zuccotti, Gian Vincenzo MD*

The Pediatric Infectious Disease Journal: October 2013 - Volume 32 - Issue 10 - p e403–e405
doi: 10.1097/INF.0b013e31829e6c9c
HIV Reports

Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.

From the *Department of Pediatrics, L. Sacco Hospital, University of Milan; Unit of Clinical Pharmacology, L. Sacco University Hospital, Università degli Studi di Milano; Consiglio Nazionale delle Ricerche Institute of Neuroscience, Milan, Italy; and §Eugenio Medea Scientific Institute, Bosisio Parini (LC), Italy.

Accepted for publication May 1, 2013.

This study was funded in part by Istituto Superiore di Sanità Grant 40H1. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Vania Giacomet, MD, Department of Pediatrics, L. Sacco Hospital, University of Milan, Italy. E-mail:

© 2013 by Lippincott Williams & Wilkins, Inc.